Journal article
Extracellular Matrix Biomimetic Hydrogels, Encapsulated with Stromal Cell-Derived Factor 1, Improve the Composition of Foetal Tissue Grafts in a Rodent Model of Parkinson’s Disease
V Penna, N Moriarty, Y Wang, KCL Law, CW Gantner, RJ Williams, DR Nisbet, CL Parish
International Journal of Molecular Sciences | Published : 2022
DOI: 10.3390/ijms23094646
Open access
Abstract
Clinical studies have provided evidence for dopamine (DA) cell replacement therapy in Parkinson’s Disease. However, grafts derived from foetal tissue or pluripotent stem cells (PSCs) remain heterogeneous, with a high proportion of non-dopaminergic cells, and display subthreshold reinnervation of target tissues, thereby highlighting the need to identify new strategies to improve graft outcomes. In recent work, Stromal Cell-Derived Factor-1 (SDF1), secreted from meninges, has been shown to exert many roles during ventral midbrain DA development and DA-directed differentiation of PSCs. Related, co-implantation of meningeal cells has been shown to improve neural graft outcomes, however, no direc..
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Awarded by Cass Foundation
Funding Acknowledgements
VP and IDL were supported by The University of Melbourne International Scholarships, Australia. CG is supported by an Australian Postgraduate Award. CP was supported by a Senior Research Fellowship provided by the National Health and Medical Research Council Australia. DN was supported by NHMRC Dementia Research Leadership Fellowship (APP1135657). This research was funded by the National Health and Medical Research Council Australia project grant APP11599265, Australian Research Council (DP200102870), Stem Cells Australia, Bethlehem Griffith Research Foundation Australia and CASS Foundation, Australia. The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and, in particular, the funding from the Operational Infrastructure Support Grant.